The weak convergence analysis plays an important role in error estimates for stochastic differential equations, which concerns with the approximation of the probability distribution of solutions. In this paper, we investigate the weak convergence order of a splitting-up method for stochastic differential equations. We first construct a splitting-up approximation, based on which we also set up a splitting-up numerical solution. We prove both of these two approximation methods are of first order of weak convergence with the help of Malliavin calculus. Finally, we present several numerical experiments to illustrate our theoretical analysis.