In this paper, we develop a simplified hybrid weighted essentially non-oscillatory (WENO) method combined with the modified ghost fluid method (MGFM) [31] to simulate the compressible two-medium flow problems. The MGFM can turn the two-medium flow problems into two single-medium cases by defining the ghost fluids state in terms of the predicted the interface state, which makes the material interface “invisible”. For the single medium flow case, we adapt between the linear upwind scheme and the WENO scheme automatically by identifying the regions of the extreme points for the reconstruction polynomial as same as the hybrid WENO scheme [55]. Instead of calculating their exact locations, we only need to know the regions of the extreme points based on the zero point existence theorem, which is simpler for implementation and saves computation time. Meanwhile, it still keeps the robustness and has high efficiency. Extensive numerical results for both one and two dimensional two-medium flow problems are performed to demonstrate the good performances of the proposed method.