In [Fu et al., JCP 305(2016): 333-359], a family of high-order targeted ENO (TENO) schemes is proposed. The weighting strategy of TENO either applies a candidate stencil with its optimal weight, or removes its contribution completely when it is crossed by discontinuities. This ENO-like stencil selection procedure significantly diminishes the numerical dissipation induced by the nonlinear adaptations of classical WENO schemes. In this paper, the fifth-order TENO scheme is extended to simulate reactive flows in combination with an uncoupled method [1, 2], which splits the reaction source term of detailed chemistry from the flow equations. A set of benchmark cases including the two-dimensional self-sustained detonation is simulated to validate and compare the performance of the fifth-order WENO and TENO schemes. Numerical experiments demonstrate that TENO scheme is robust for simulating chemical reacting flows with using the uncoupled method. In particular, TENO scheme shows better performance in capturing both the shockwaves and the small-scale flow structures, e.g. shear layers and vortices.