TY - JOUR T1 - Mechanism of Anticancer Effects of Antimicrobial Peptides AU - Xuan Liu, Yi Li, Zhi Li, Xiqian Lan, Polly Hang-mei Leung, Jiashen Li, Mo Yang, Frank Ko & Ling Qin JO - Journal of Fiber Bioengineering and Informatics VL - 1 SP - 25 EP - 36 PY - 2015 DA - 2015/08 SN - 8 DO - http://doi.org/10.3993/jfbi03201503 UR - https://global-sci.org/intro/article_detail/jfbi/4683.html KW - Antimicrobial Peptides KW - Anticancer Activity KW - Electrostatic Attraction KW - Hydrophobic Interaction KW - Anticancer Drug Resistance AB - Antimicrobial Peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contribute to the potential mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective targeting properties make AMPs promising candidates for alternative approach to solve the problems from anticancer drug resistance.

Xuan Liu, Yi Li, Zhi Li, Xiqian Lan, Polly Hang-mei Leung, Jiashen Li, Mo Yang, Frank Ko and Ling Qin. (2015). Mechanism of Anticancer Effects of Antimicrobial Peptides. Journal of Fiber Bioengineering and Informatics. 8 (1). 25-36. doi:10.3993/jfbi03201503