TY - JOUR
T1 - Mechanism of Anticancer Effects of Antimicrobial Peptides
AU - Xuan Liu, Yi Li, Zhi Li, Xiqian Lan, Polly Hang-mei Leung, Jiashen Li, Mo Yang, Frank Ko & Ling Qin
JO - Journal of Fiber Bioengineering and Informatics
VL - 1
SP - 25
EP - 36
PY - 2015
DA - 2015/08
SN - 8
DO - http://doi.org/10.3993/jfbi03201503
UR - https://global-sci.org/intro/article_detail/jfbi/4683.html
KW - Antimicrobial Peptides
KW - Anticancer Activity
KW - Electrostatic Attraction
KW - Hydrophobic Interaction
KW - Anticancer Drug Resistance
AB - Antimicrobial Peptides (AMPs) were first known as a group of innate immune products that mainly
targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs
toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between
AMPs (cationic AMPs) and microbial cell membranes. These effects also contribute to the potential
mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells
and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective
targeting properties make AMPs promising candidates for alternative approach to solve the problems
from anticancer drug resistance.