TY - JOUR
T1 - Bio-inspired Electrospun Fibre Structures - Numerical Model
AU - Budimir Mijovic & Ante Agic
JO - Journal of Fiber Bioengineering and Informatics
VL - 1
SP - 23
EP - 32
PY - 2013
DA - 2013/06
SN - 6
DO - http://doi.org/10.3993/jfbi03201302
UR - https://global-sci.org/intro/article_detail/jfbi/4818.html
KW - Electrospun PCL
KW - Multiscale
KW - Numerical Model
AB - A systems approach that integrates processing, structure, property and performance relations has
been used in the design of multilevel-structured fibrous materials. For electrospun fibrous structure,
numerical implementation of multiscale materials philosophy provides a hierarchy of computational
models defining design parameters that are integrated through computational continuum mechanics.
Electrospun micro/nano (multiscale) poly(ε-caprolactone) (PCL) fibrous scaffolds were studied. The
fibrous structures were evaluated for their mechanical, morphological and cell attachment properties.
The cell attachment studies showed that cell activity on multi-scale scaffolds was higher compared to
micro-fibrous scaffolds. These results suggest that the combination of a micro- and nano-fiber hierarchical
scaffold could be more beneficial for tissue engineering applications than for individual scaffolds.