TY - JOUR
T1 - Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials
AU - Tian Zhou , Xiumei Mo & Jiao Sun
JO - Journal of Fiber Bioengineering and Informatics
VL - 3
SP - 319
EP - 325
PY - 2014
DA - 2014/07
SN - 7
DO - http://doi.org/10.3993/jfbi09201402
UR - https://global-sci.org/intro/article_detail/jfbi/4788.html
KW - Collagen
KW - Chitosan
KW - Nanofibers
KW - L929 Cell
AB - The objective of this study was to develop an original anti-bacterial material for skin wound healing.
Collagen-chitosan nanofibrous membranes were fabricated by electrospinning. The morphology, tensile
strength and contact angle of the membranes were measured. In addition, cell adhesion and proliferation
on the membranes were evaluated. The antimicrobial property against Staphylococcus aureus of the
membranes was also determined. The results indicated that the diameter of electrospun collagen-chitosan
nanofibrous membranes was 221 ± 105 nm, the tensile strength was 1.53 ± 0.12 Mpa and the contact angle
was 42.44 ± 4.03 ° . Besides, the collagen-chitosan nanofibrous membranes promoted cell attachment and
proliferation and also inhibited the growth of Staphylococcus aureus. In conclusion, these data suggest
that electrospun collagen-chitosan nanofibrous membranes have potential to serve as skin wound healing
materials, which might be ascribed to its favorable mechanical strength, excellent cell affinity, as well as
good antimicrobial properties against Staphylococcus aureus.