TY - JOUR
T1 - Preparation and Characterization of the Silk Fibroin 3D Scaffolds with Porous and Interconnected Structure
AU - Song , Jun
AU - Wang , Xiaoqin
AU - Li , Jiashen
JO - Journal of Fiber Bioengineering and Informatics
VL - 4
SP - 183
EP - 195
PY - 2019
DA - 2019/02
SN - 11
DO - http://doi.org/10.3993/jfbim00288
UR - https://global-sci.org/intro/article_detail/jfbi/13008.html
KW - Silk fibroin
KW - Paraffin spheres
KW - Tissue engineering
KW - Porous scaffold.
AB - <p>Silk fibroin (SF) is wildly used in the field of biomedical science. Considering the contradiction between
suitable pore size and outstanding mechanical properties, this research focused on the topic of preparing
the 3D scaffolds with large pore sizes and high interconnectivity. For preparing the silk fibroin 3D scaffold
samples, three kinds of porogens were applied in two methods which paraffin spheres were used in freezedrying. Sodium chloride (NaCl) and sodium carbonate (Na<sub>2</sub>CO<sub>3</sub>) were used in leaching respectively.
Different pore size of porogens were used to control the pore size and porosities of prepared scaffold
samples. Some basic properties of scaffold samples were characterized including surface morphology,
chemical structure, porosity and mechanical performance. The best porosity of sample reached to 93%
in the research.</p>