@Article{JFBI-5-309,
author = {Ai-Zheng Chen, Guang-Ya Wang, Shi-Bin Wang, Jian-Gang Feng, Yuan-Gang Liu and Wei Zheng},
title = {Preparation of Ibuprofen-loaded Poly-(Methyl Vinyl Ether-co-maleic Anhydride) Nanoparticles by Solution-enhanced Dispersion by Supercritical CO<sub>2</sub>},
journal = {Journal of Fiber Bioengineering and Informatics},
year = {2012},
volume = {5},
number = {3},
pages = {309--320},
abstract = {Ibuprofen-loaded Poly-(methyl vinyl ether-co-maleic anhydride) (PVM/MA) nanoparticles were
successfully prepared by Solution-enhanced Dispersion by Supercritical CO_2 (SEDS). Ibuprofen and
PVM/MA were first homogeneously dissolved in acetone, and then the resulting solution was
simultaneously sprayed with supercritical CO_2 through a coaxial nozzle, forming ibuprofen-PVM/MA
nanoparticles. FTIR spectra demonstrated that ibuprofen was successfully incorporated into PVM/MA
and the SEDS process was a typically physical process. The absolute value of the zeta potential of the
obtained ibuprofen-PVM/MA nanoparticles was larger than 40 mV, indicating a good stability of the
nanoparticles in aqueous suspension and suitability for oral administration. Analysis of
Thermogravimetry-differential Scanning Calorimetry (TG-DSC) revealed that the effect of the SEDS
process on the thermostability of the drug and the coating polymer was negligible. The results of Gas
Chromatography (GC) analysis confirmed that the SEDS process could efficiently remove the organic
residue. The drug dosage of 20% corresponded to a final drug load of 5.3 ± 0.2%, which appeared to be
relatively low and indicated that most of the ibuprofen was lost in the supercritical CO_2. Significant
differences existed among the drug release profiles obtained from different release media; a medium
with a low pH could efficiently prevent the release of ibuprofen from ibuprofen-PVM/MA nanoparticles,
which works to reduce the adverse effects of ibuprofen on the stomach and makes ibuprofen-PVM/MA
nanoparticles suitable for oral administration.},
issn = {2617-8699},
doi = {https://doi.org/10.3993/jfbi09201209},
url = {http://global-sci.org/intro/article_detail/jfbi/4885.html}
}