@Article{CiCP-23-440,
author = {Wei Yao, Huaxiong Huang and Robert M. Miura },
title = {Role of Astrocyte in Cortical Spreading Depression: A Quantitative Model of Neuron-Astrocyte Network},
journal = {Communications in Computational Physics},
year = {2018},
volume = {23},
number = {2},
pages = {440--458},
abstract = {<p style="text-align: justify;">Cortical spreading depression (CSD) involves depolarization of neurons and
astrocytes due principally to a large increase in extracellular potassium. CSD is also
accompanied by large increases in extracellular ATP and is blocked by glutamate N-methyl-D-aspartate
(NMDA) receptor antagonists. In a previous study, we used a neuronal
model to investigate the instigation of CSD and propagation of CSD wave by
increasing extracellular potassium. In this paper, we extend that model by constructing
a neuron-astrocyte network and incorporating the effects of ATP via the coupled
biochemical pathways involving glutamate and NMDA currents. We show that both
the electrical current stimuli and the local elevation in the extracellular ATP or glutamate
concentration can lead to CSD in the coupled neuron-astrocyte model, while
ATP or glutamate increase fails to induce CSD when the glutamate NMDA channels
are blocked. These results can explain both the potassium theory postulated by Grafstein
and glutamate theory by Van Harreveld. Our model showed extracellular potassium
plays the key role in CSD instigation and propagation, and glutamate is a key
compound mediating CSD by activating NMDA channels through neuron-astrocyte
interactive.</p>},
issn = {1991-7120},
doi = {https://doi.org/10.4208/cicp.OA-2016-0262},
url = {http://global-sci.org/intro/article_detail/cicp/10532.html}
}